On the role of CD8 T cells in determining recovery time from influenza virus infection

P Cao; Z Wang; AWC Yan; J McVernon; J Xu; JM Heffernan; K Kedzierska; JM McCaw

Journal article

On the role of CD8 T cells in determining recovery time from influenza virus infection

P Cao, Z Wang, AWC Yan, J McVernon, J Xu, JM Heffernan, K Kedzierska, JM McCaw

Frontiers in Immunology | FRONTIERS MEDIA SA | Published : 2016

DOI: 10.3389/fimmu.2016.00611

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Abstract

Myriad experiments have identified an important role for CD8+ T cell response mechanisms in determining recovery from influenza A virus infection. Animal models of influenza infection further implicate multiple elements of the immune response in defining the dynamical characteristics of viral infection. To date, influenza virus models, while capturing particular aspects of the natural infection history, have been unable to reproduce the full gamut of observed viral kinetic behavior in a single coherent framework. Here, we introduce a mathematical model of influenza viral dynamics incorporating innate, humoral, and cellular immune components and explore its properties with a particular emphas..

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University of Melbourne Researchers

Pengxing Cao Author

Jodie McVernon Author

Katherine Kedzierska Author

James McCaw Author

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Grants

Awarded by National Health and Medical Research Council

Funding Acknowledgements

PC is supported by an Australian Government National Health and Medical Research Council (NHMRC) funded Centre for Research Excellence in Infectious Diseases Modelling to Inform Public Health Policy. ZW is supported by an NHMRC Australia-China Exchange Fellowship. AY is supported by an Australian Postgraduate Award. JM and KK are support by NHMRC Career Development and Senior Researcher Fellowships, respectively. JMM is supported by an Australian Research Council Future Fellowship. JH is supported by Natural Sciences and Engineering Research Council of Canada (NSERC). The H7N9 Clinical Study was supported by National Natural Science Foundation of China (NFSC) grants 81471556, 81470094, and 81430030.